Table 2 Univariate/multivariate Cox analysis showing that FAM111B can be used as an independent prognostic risk factor for glioma

Age

695

<=60

552

Reference

>60

143

4.668 (3.598-6.056)

<0.001

1.484 (1.089-2.023)

0.013

Gender

695

Female

297

Reference

Male

398

1.262 (0.988-1.610)

0.062

1.226 (0.933-1.611)

0.144

WHO grade

634

G2

223

Reference

G3

243

2.999 (2.007-4.480)

<0.001

1.785 (1.150-2.771)

0.010

G4

168

18.615 (12.460-27.812)

<0.001

3.874 (2.129-7.047)

<0.001

IDH status

685

WT

246

Reference

Mut

439

0.117 (0.090-0.152)

<0.001

0.276 (0.181-0.421)

<0.001

1p/19q codeletion

688

codel

170

Reference

noncodel

518

4.428 (2.885-6.799)

<0.001

1.246 (0.693-2.237)

0.462

Histological type

695

Astrocytoma

195

Reference

Glioblastoma

168

6.791 (4.932-9.352)

<0.001

Oligoastrocytoma

134

0.657 (0.419-1.031)

0.068

1.223 (0.746-2.006)

0.424

Oligodendroglioma

198

0.580 (0.395-0.853)

0.006

0.870 (0.528-1.434)

0.586

FAM111B

695

2.107 (1.871-2.373)

<0.001

1.310 (1.115-1.539)

0.001