Table 3 Univariate Cox analysis of factors for OS, PFS, and SAP in CCGA
Variables | OS | PFS | SAP | |||
|---|---|---|---|---|---|---|
HR (95%CI) | p value | HR (95%CI) | p value | HR (95%CI) | p value | |
Age | ||||||
< 60 vs. ≥ 60 | 1.30 (0.99–1.71) | 0.06 | 1.27 (0.97–1.66) | 0.08 | 1.09 (0.83–1.44) | 0.53 |
Gender | ||||||
Male vs. Female | 1.14 (0.90–1.43) | 0.29 | 1.12 (0.90–1.40) | 0.32 | 1.15 (0.91–1.45) | 0.24 |
Grade | ||||||
3 vs. 4 | 2.06 (1.60–2.67) | 0.00 | 1.97 (1.54–2.50) | 0.00 | 1.42 (1.12–1.81) | 0.00 |
TCGA subtype | 0.94 (0.75–1.17) | 0.56 | 1.01 (0.81–1.26) | 0.92 | 0.85 (0.69–1.04) | 0.11 |
MGMT methylation | ||||||
Yes vs. no | 0.65 (0.50–0.84) | 0.00 | 0.75 (0.58–0.96) | 0.02 | 0.68 (0.52–0,87) | 0.00 |
IDH1 mutation | ||||||
Yes vs. no | 0.62 (0.45–0.86) | 0.00 | 0.64 (0.47–0.88) | 0.01 | 0.77 (0.56–1.06) | 0.11 |
TP53 mutation | ||||||
Yes vs. no | 1.16 (0.72–1.89) | 0.54 | 1.15 (0.71–1.86) | 0.58 | 1.04 (0.65–1.69) | 0.86 |
EGFR amplification | ||||||
Yes vs. no | 0.65 (0.36–1.17) | 0.15 | 0.82 (0.48–1.42) | 0.48 | 0.59 (0.33–1.06) | 0.08 |
Ki-67 expression | ||||||
0–1 vs. 2–3 | 1.71 (1.25–2.34) | 0.00 | 1.64 (1.21–2.23) | 0.00 | 1.40 (1.03–1.92) | 0.03 |
LOH1p/19q | ||||||
Yes vs. no | 0.66 (0.41–1.07) | 0.09 | 0.66 (0.41–1.06) | 0.09 | 0.75 (0.46–1.21) | 0.24 |
Involved lobe | ||||||
Single vs. multiple | 1.03 (0.81–1.31) | 0.79 | 1.00 (0.80–1.27) | 0.97 | 1.02 (0.81–1.29) | 0.87 |
Resection | ||||||
Total vs. subtotal | 0.97 (0.76–1.24) | 0.78 | 0.97 (0.77–1.24) | 0.82 | 1.07 (0.84–1.36) | 0.61 |
Operation after progression | ||||||
Yes vs. no | 1.17 (0.80–1.72) | 0.41 | NA | NA | 0.98 (0.67–1.43) | 0.90 |
TMZ after progression | ||||||
Yes vs. No | 1.36 (0.86–2.15) | 0.19 | NA | 1.12 (0.71–1.76) | 0.64 | |
Therapy | ||||||
Standard vs. unstandard | 0.86 (0.67–1.09) | 0.21 | 0.94 (0.74–1.18) | 0.59 | 0.86 (0.67–1.10) | 0.22 |