Fig. 4
From: Diffuse intrinsic pontine glioma: current insights and future directions
Targetable transcriptional dependencies in DIPGs. DIPGs can also be targeted pharmacologically at the DNA level by leveraging the transcriptional dependencies of the tumor. Transcriptional disruption has been demonstrated to reduce tumor growth via bromodomain (a) or CDK7 (b) inhibition using JQ1 or THZ1, respectively